Literature summary extracted from

Xu, X.; Yu, T.; Shi, J.; Chen, X.; Zhang, W.; Lin, T.; Liu, Z.; Wang, Y.; Zeng, Z.; Wang, C.; Li, M.; Liu, C.
Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer (2014), J. Biol. Chem., 289, 8881-8890.

Protein Variants

EC Number	Protein Variants	Comment	Organism
3.2.2.29	D133A	the mutation significantly reduces the enzymes ability to enhance Wnt signaling	Homo sapiens
3.2.2.29	N140A	inactive	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.2.2.29	nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.2.2.29	thymine-mismatched double-stranded DNA + H2O	Homo sapiens	-	thymine + double-stranded DNA with abasic site	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.2.2.29	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.2.2.29	colorectal cancer cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.2.2.29	thymine-mismatched double-stranded DNA + H2O	-	Homo sapiens	thymine + double-stranded DNA with abasic site	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.2.2.29	TDG	-	Homo sapiens
3.2.2.29	thymine DNA glycosylase	-	Homo sapiens

Expression

EC Number	Organism	Comment	Expression
3.2.2.29	Homo sapiens	in colorectal cancer patients, enzyme levels are significantly higher in tumor tissues than in the adjacent normal tissues	up

General Information

EC Number	General Information	Comment	Organism
3.2.2.29	malfunction	enzyme knockdown by shRNAs inhibits the proliferation of colorectal cancer cells in vitro and in vivo	Homo sapiens
3.2.2.29	physiological function	thymine DNA glycosylase up-regulates Wnt signaling by interacting with the transcription factor TCF4 and coactivator CREB-binding protein/p300 in the Wnt pathway	Homo sapiens

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Release 2023.1 (January 2023)